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Although the rate of CDI among hospitalized pregnant women historically has been as low as 0. 02, a report of 10 cases of peripartum CDI with a 40 hospitalization rate and one fatality brought attention to this new potentially high-risk subgroup (141,142,143,165). Most of these women had a history of recent antibiotic use (9 of 10 patients in one series or hospitalization (165).
Another report found recent Cesarean section appears to confer a higher risk for CDI than vaginal delivery (142). The rate of maternal and fetal mortality in patients with severe CDI remains high (30) with 5 of 10 patients in one series developing toxic megacolon (165).