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The results from the pharmacokinetic analysis of MBZ in plasma, parasite and tissues of mice proved that the improved treatment efficacy was resulted from the higher drug concentration in plasma and parasite. Therefore, the drug concentrations in cyst fluid and cyst wall were determined by that in the plasma. And in MBZ-OS groups, both of the drug levels in plasma and parasite increased. That was, the AUC 0-t values of plasma, cyst fluid and cyst wall were 7.