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Though both approaches can suffer from estimation challenges, we recommend employing the one-stage method, as it uses a more exact statistical approach and accounts for parameter correlation. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: Whilst undertaking this work, TPD, GAZ and RDR were supported by the MRC Midlands Hub for Trials Methodology Research (Medical Research Council Grant ID G0800808), at the University of Birmingham in the United Kingdom. The authors also gratefully acknowledge the financial support by The Netherlands Organization for Scientific Research (9120.